β-Adrenergic regulation of proinflammatory cytokines in humans
نویسندگان
چکیده
منابع مشابه
Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells
OBJECTIVE Proinflammatory cytokines are cytotoxic to beta-cells and have been implicated in the pathogenesis of type 1 diabetes and islet graft failure. The importance of the intrinsic mitochondrial apoptotic pathway in cytokine-induced beta-cell death is unclear. Here, cytokine activation of the intrinsic apoptotic pathway and the role of the two proapoptotic Bcl-2 proteins, Bad and Bax, were ...
متن کاملProinflammatory Cytokines in Peritonitis
RATIONALE We performed this study with the purpose of revealing different aspects of the systemic inflammatory response syndrome in peritonitis. OBJECTIVES The aim of the presentation was to make a research on some of the immune response mediators in secondary peritonitis and to observe their capacity to anticipate the evolution towards septic complications. METHODS AND RESULTS We have unde...
متن کاملRegulation of Nitric Oxide Synthesis by Proinflammatory Cytokines
We have examined cytokine regulation of nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HUVEC). 24-h treatment with IFN-'y (200 U/ml) plus TNF (200 U/ml) or IL-1,8 (5 U /ml) increased NOS activity in HUVEC lysates, measured as conversion of I '4CIL-arginine to [ '4Cj L-citrulline. Essentially, all NOS activity in these cells was calcium dependent and membrane associated. ...
متن کاملInvolvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic β-Cells
OBJECTIVE Pancreatic beta-cells exposed to proinflammatory cytokines display alterations in gene expression resulting in defective insulin secretion and apoptosis. MicroRNAs are small noncoding RNAs emerging as key regulators of gene expression. Here, we evaluated the contribution of microRNAs to cytokine-mediated beta-cell cytotoxicity. RESEARCH DESIGN AND METHODS We used global microarray p...
متن کاملRegulation of cardiac alternans by β-adrenergic signaling pathways.
In cat atrial myocytes, β-adrenergic receptor (β-AR) stimulation exerts profound effects on excitation-contraction coupling and cellular Ca(2+) cycling that are mediated by β(1)- and β(2)-AR subtypes coupled to G proteins (G(s) and G(i)). In this study, we determined the effects of β-AR stimulation on pacing-induced Ca(2+) alternans. Ca(2+) alternans was recorded from single cat atrial myocytes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2000
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0801311